Glycosylation Control Becomes Priority in Biologics Development
Drug manufacturers must now prioritize glycosylation control in the development of complex biologics, including bispecific antibodies, antibody-drug conjugates, and Fc-fusion proteins. These newer therapeutics are sensitive to glycan heterogeneity, which can directly affect their efficacy and consistency. Historically, manufacturers addressed glycosylation issues during downstream processing. However, modern biologics require proactive upstream quality engineering to mitigate…









