Microneedle-based vaccine patches could help address some of the formulation, storage, and administration challenges limiting broader deployment of messenger RNA (mRNA) vaccines, according to a review published in AAPS Open. The review examines how microneedle technology could improve vaccine stability, simplify administration, and support more consistent immunization schedules.
Although mRNA vaccines demonstrated their potential during the COVID-19 pandemic, widespread distribution remains complicated by temperature-sensitive formulations, cold-chain requirements, and the need for multiple doses. The researchers identify delivery and formulation engineering as important areas for addressing these limitations.
Microneedle patches offer an alternative to conventional injections by delivering vaccine formulations into the skin, where immune cells can initiate immune responses. This approach may also reduce the amount of antigen needed to achieve protection while eliminating conventional needles and associated sharps waste.
The review highlights dissolving microneedle patches as a promising option for mRNA delivery. These devices use biodegradable, water-soluble polymers to encapsulate lipid nanoparticle-based mRNA formulations. Researchers are investigating polymers to protect sensitive mRNA formulations during storage and delivery. Successful development will depend on balancing several formulation and manufacturing variables.
Source: drug-dev.com · Image: Bottle for Enovid 10 mg Oral Contraceptive – DPLA – 0cc9d42b69b6fd3d586205f5831cade0 by G.D. Searle & Co, CC BY 4.0, via Wikimedia Commons
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