New research from Michigan State University reveals that hormone-regulated immune cells, specifically monocytes, may contribute to the prolonged experience of chronic pain in women compared to men. The study indicates that a subset of monocytes, which releases the anti-inflammatory cytokine interleukin-10 (IL-10), is more active in males, potentially due to higher testosterone levels. This finding aligns with observations that men resolve pain from traumatic injuries more quickly than women, suggesting a biological basis for sex differences in pain resolution.
The implications of this research are significant for the development of therapeutics targeting sex-biased chronic pain conditions. By understanding the immune mechanisms at play, researchers may be able to manipulate monocytes to enhance IL-10 production, offering a pathway for non-opioid pain relief strategies. As chronic pain affects over 100 million individuals in the U.S., these insights could lead to more effective management and treatment options tailored to gender-specific responses. The study underscores the need for a deeper understanding of the immune system’s role in pain, shifting the focus from merely blocking pain signals to actively promoting pain resolution.
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